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  • Oliver Burk, Katja A Arnold, +6 authors Michel Eichelbaum
  • Biology, Medicine
  • Molecular Pharmacology
  • 2005 (First Publication: 1 June 2005)
  • Artemisinin drugs are of utmost importance in the treatment of malaria, because they represent the sole class of therapeutically used antimalarial drugs to which malaria parasites have not yetExpand
  • Mikko Niemi, Elke Schaeffeler, +9 authors Kari T. Kivistö
  • Biology, Medicine
  • Pharmacogenetics
  • 2004 (First Publication: 1 July 2004)
  • This study aimed to characterize possible relationships between polymorphisms in the drug transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (SLCO2B1), multidrugExpand
  • Elke Schaeffeler, Christine Stebler Fischer, +5 authors Matthias Schwab
  • Medicine, Biology
  • Pharmacogenetics
  • 2004 (First Publication: 1 July 2004)
  • The thiopurine S-methyltransferase (TPMT) genetic polymorphism has a significant clinical impact on the toxicity of thiopurine drugs. It has been proposed that the identification of patients who areExpand
  • Anne T Nies, Hermann Koepsell, +7 authors Elke Schaeffeler
  • Medicine, Biology
  • Hepatology
  • 2009 (First Publication: 1 October 2009)
  • UNLABELLED An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic cation transporters (OCTs) ofExpand
  • Klaus Fellermann, Daniel E Stange, +9 authors Eduard F Stange
  • Biology, Medicine
  • American journal of human genetics
  • 2006 (First Publication: 1 September 2006)
  • Defensins are endogenous antimicrobial peptides that protect the intestinal mucosa against bacterial invasion. It has been suggested that deficient defensin expression may underlie the chronicExpand
  • Matthias Schwab, Ulrich M. Zanger, +9 authors Michel F Eichelbaum
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2008 (First Publication: 1 May 2008)
  • PURPOSE To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate reductase (MTHFR ) and of nongeneticExpand