Elke Maas

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Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD reporter transgene in naive mESCs correlated with lower levels of(More)
Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output in endothelial cells is highly context- and dose-dependent. Phosphorylation of the BMP intracellular effectors, SMAD1/5/9, is routinely used to(More)
Heparan sulfate (HS) proteoglycans comprising HS glycos-aminoglycan chains (HS-chains) and core proteins function in the membrane and extracellular matrix (ECM) as co-receptors for growth factors; i.e., they modulate activity of signaling factors via controlling their extracellular stabilization and movement. However, precise mechanisms by which HS-chains(More)
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