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Cocaine was administered i.v. to decerebrate cats while monitoring cardiac preganglionic sympathetic nerve activity (SNA), arterial blood pressure (BP) and heart rate (HR). Cocaine, 4 mg/kg i.v., reduced SNA by 55 +/- 6%, but did not significantly affect BP or HR. Cocaine, in doses that were ineffective by the i.v. route, was administered into the vertebral(More)
BACKGROUND The current study was conducted to evaluate the efficacy of sorafenib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, when added to standard radiotherapy and temozolomide in the first-line treatment of patients with glioblastoma multiforme. METHODS After initial surgical resection or biopsy, patients with newly(More)
PURPOSE Sorafenib, an oral multikinase inhibitor, has shown preliminary activity in non-small-cell lung cancer (NSCLC). Patients with advanced NSCLC were treated with erlotinib with or without sorafenib in this multicenter phase II trial. PATIENTS AND METHODS Key eligibility criteria included the following: stage IIIB or IV NSCLC; one to two prior(More)
In the present study, we have applied antiserum to thyrotropin-releasing hormone (TRH) and avidin-biotin immunocytochemistry to determine the distribution of TRH-like immunoreactivity in the vagal nuclei of the cat. A dense network of TRH-immunoreactive (TRH-IR) fibers and terminals is noted in the dorsal motor nucleus of the vagus (DMV) from 0 to 2.5 mm(More)
Empirical evidence suggests that early home environments characterized by low care and high overprotection are positively associated with the adult expression of anxiety. While available evidence supports this position for European Americans, there has been no examination of the relationship between perceived parental rearing practices and anxiety among(More)
Neuropeptide Y-like immunoreactive (NPY-LI) perikarya and processes have been identified in the medulla of the cat. NPY-LI perikarya were found in 4 regions; (1) the medial N. of the solitary tract (MNTS), (2) the lateral tegmental field (LTF), (3) the ventrolateral medullary surface (VLMS), and (4) in the spinal trigeminal nucleus. Tyrosine(More)
4659 Background: Pazopanib, a multi-targeted inhibitor of VEGFR, PDGFR, and c-KIT, is an active first-line agent in the treatment of advanced renal cell carcinoma (RCC). The efficacy of pazopanib in patients (pts) who have progressed on other anti-angiogenesis agents, particularly sunitinib, is unclear. METHODS Pts with metastatic clear-cell RCC who had(More)
Urapidil is thought to lower blood pressure by both a peripheral and a central mechanism. The former effect is caused by blockade of alpha-1 adrenoceptors whereas the latter effect has been shown to occur in the medulla, specifically at the intermediate area on the ventral surface of the medulla. The receptor mediating the central effect is not the alpha-1(More)
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