Elke Bleifuss

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The mouse cytomegaloviral (MCMV) protein pM27 represents an indispensable factor for viral fitness in vivo selectively, antagonizing signal transducer and activator of transcription 2 (STAT2)-mediated interferon signal transduction. We wished to explore by which molecular mechanism pM27 accomplishes this effect. We demonstrate that pM27 is essential and(More)
The goal of immune-based tumor therapies is the activation of immune cells reactive against a broad spectrum of tumor-expressed antigens. Vaccines based on chaperone proteins appear promising as these proteins naturally exist as complexes with various protein fragments including those derived from tumor-associated antigens. Multi-chaperone systems are(More)
Ifosfamide is a DNA-alkylating agent used frequently in chemotherapy of human malignancies. Ifosfamide and its major decomposition products deplete intracellular glutathione (GSH). Glutathione is the major intracellular thiol reductant that protects cells against oxidative injury. Ifosfamide depletion of intracellular GSH in human dendritic cells (DC), T(More)
Cell-penetrating peptides (CPPs) have been shown to improve antigen loading of dendritic cell vaccines. Here we asked whether fusion of a CPP to a protein improves its immunogenicity when this fusion protein is directly applied as vaccine. We used the cell-penetrating translocation motif (TLM) derived from the hepatitis B virus, because no size limitation(More)
Die nachfolgend beschriebenen Forschungsprojekte der Nachwuchsgruppe I am Robert Koch-Institut (RKI) befassen sich am Beispiel des Hepatitis-B-Virus (HBV) mit der Charakterisierung intrazellulärer Signalkaskaden und der Analyse ihrer Bedeutung für den viralen Lebenszyklus (Replikaktionsprozess) sowie für die Entstehung von HBV assoziierten Tumoren. Darüber(More)
Nancy Baenziger Cynthia Baldwin Antonio Bandeira Menashe Bar-Eli Rolf Barth Jirina Bartunkova Susanne Beckebaum Jürgen Becker Christian Beltinger Baya Benyahiya Philip Bergman Wolfgang Bethge Jeff Bidwell Angelika Bierhaus Silvia Biocca Arya Biragyn Angelika Bischof Delaloye Gail Bishop Elke Bleifuss Otto C. Boerman Bjarne Bogen Ernest Borden Hossein(More)
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