Elizavrta Alperina

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The involvement of the dopaminergic (DAergic), GABAergic and serotoninergic (5-HTergic) synaptic mechanisms in neuroimmunomodulation are considered. It is shown that the central DA- and GABAergic systems exert a stimulatory influence on the immune reactivity. Activation of postsynaptic DA receptors with apomorphine and(More)
Bilateral electrolytic destruction of the brain areas containing dopamine (DA) cell bodies (nuclei A9 and A10) as well as terminal regions of the nigrostriatal and mesolimbic DAergic systems (nuclei caudatus and accumbens) resulted in a considerable decrease in the intensity of the immune response in rats immunized with sheep red blood cells (SRBC).(More)
Immune responses in two strains of male mice with aggressive and submissive behavior patterns was studied. In aggressive CBA males immunized on the 10th day of agonistic confrontations with submissive partners, greater numbers of plaque-forming cells (PFC) and rosette-forming cells (RFC) were noted compared to control mice. Unlike the CBA strain, both PFC(More)
The production of submissive behavior in C57BL/6J mice during 10 or 20 days of social confrontations resulted in increases in serotonin (5-HT) content in the amygdala, hippocampus, nucleus caudatus, Al1, A10, A9, and hypothalamus. The level of 5-hydroxyindolacetic acid (5-HIAA) was higher in most structures after 20 daily encounters compared to animals(More)
The intraimmune pathways and mechanisms of action of the serotoninergic and dopaminergic systems in exerting a modulating effect upon immunogenesis are presented. Experiments were carried out in mice immunized with sheep red blood cells (1 X 10(7); 5 X 10(6)). Participation of the hypothalamic-pituitary complex in the monoaminergic mechanisms of stimulation(More)
Enhanced immune response of aggressive CBA mice after 10 daily confrontations in sensory contact on day 4 after immunization with sheep red blood cells (5×108) is paralleled by an increase in the count of CD4+ T-cells in the bone marrow. Aggressive behavior, weight of the spleen, and count of CD4+ T-helpers in the bone marrow (which is increased only in(More)
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