Elizaveta I Ratner

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The beginning of Vakhmistrov’s research career at the Institute of Plant Physiology was a favorable period for the young scientist, because it coincided with the period when Academician A.L. Kursanov initiated renovation of the methodological bases. At the institute, the functional electron microscopy was established and the methods of biochemistry and(More)
Binding of 3H-mibefradil (Ro-40-5967, CAS 116666-63-8) and 3H-desmethoxyverapamil (CAS 67018-79-5) to membranes of vascular smooth muscle cells (VSMC) and heart was studied. Direct binding studies in VSM demonstrated the presence of significantly higher amounts of binding sites for mibefradil as compared to those for verampamil. In competition experiments(More)
Myofibroblasts are involved in vessel remodeling during the development of hypertension as well as after angioplasty and aortocoronary grafting, but the mechanisms of myofibroblastic phenotypic modulation are not fully elucidated. We assessed the role of urokinase plasminogen activator (uPA) and its proteolytic activity in myofibroblast differentiation and(More)
In cultured fibroblasts, urokinase stimulated expression of MMP-9 and generation of ROS, while antioxidant ebselen abolished the stimulating effect of urokinase on MMP-9 expression. sTNF-α produced similar and more pronounced stimulating effect. The data showed that urokinase could regulate MMP-9 expression via ROS generation in fibroblasts, which can play(More)
In the last years stem cells (SC) have been identified in rodent and human hearts. These cells have ability to multilineage differentiation in vitro and in vivo and improve cardiac function. The development of new methods of isolation SC offers new approaches to cardiac regeneration. However, the question of how individual patient characteristics influence(More)
Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent inflammation; however, the link between(More)
We studied the effect of urokinase, its recombinant forms, and domain fragments on migration and proliferation of adipose tissue mesenchymal stromal cells (MSCs) and MMP secretion by these cells. Urokinase, but not its recombinant forms, slightly induced directed migration of MSCs. Spontaneous migration of MSCs increased under the action of urokinase or its(More)
The membranotropic action of many drugs is complex and includes both the basic mechanisms of action on the cell membrane and also other, less marked effects. We know, for instance, that the pharmacologic effect of neuroleptics is exerted through the blockade of dopamine receptors (DR) of the brain, but many of them are also antagonists of histamine(More)
Interaction of the antiarrhythmics moracizine (moricizine, ethmozine, ETHM) and ethacizine (ETHA), the ethyl ester hydrochlorides of 10-(3-R-propionyl)-phenothiazine-2-carbamic acid (where R is morpholine or diethylamine, respectively), with muscarinic cholinergic alpha- and beta-adrenergic systems and histamine H1 receptors (H1-R) has been studied. ETHA(More)