Elizabeth W. Loder

Learn More
Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement is an attempt to consolidate and update previous health economic(More)
BACKGROUND Economic evaluations of health interventions pose a particular challenge for reporting because substantial information must be conveyed to allow scrutiny of study findings. Despite a growth in published reports, existing reporting guidelines are not widely adopted. There is also a need to consolidate and update existing guidelines and promote(More)
1 Rotman Institute of Philosophy, Department of Philosophy, Western University, London, Ontario, Canada, 2 Department of Medicine, Western University, London, Ontario, Canada, 3 Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada, 4 Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario,(More)
Susceptibility to migraine is determined by genetic factors and is therefore subject to the forces of natural selection. Migraine is a common and ancient disorder whose prevalence may be increasing, suggesting that a migraine-prone nervous system may be associated with reproductive or survival advantages. Five evolutionary explanations are reviewed that(More)
BACKGROUND The strikingly higher prevalence of migraine in females compared with males is one of the hallmarks of migraine. A large global body of evidence exists on the sex differences in the prevalence of migraine with female to male ratios ranging from 2:1 to 3:1 and peaking in midlife. Some data are available on sex differences in associated symptoms,(More)
BACKGROUND AND OBJECTIVES The US National Center for Health Statistics, which is part of the Centers for Disease Control, conducts ongoing public health surveillance activities. The US Armed Forces also maintains a comprehensive database of medical information. We aimed to identify the most current prevalence estimates of migraine and severe headache in the(More)
OBJECTIVE To describe the patterns of medical treatment for migraineurs in the United States. BACKGROUND Over the past decade, many new treatments for migraine have become available and awareness of migraine has improved. However, there is little information about the patterns of medical treatment in the US society. DESIGN/METHODS A validated(More)
n engl j med 363;1 nejm.org july 1, 2010 63 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal(More)
OBJECTIVE To compare the proportion of patients who prefer rizatriptan orally disintegrating tablet (ODT) 10-mg to sumatriptan 50-mg tablet. BACKGROUND Migraineurs express treatment preference based on a variety of attributes including the speed of pain relief and medication formulation. Rizatriptan ODT is an orally disintegrating formulation of(More)
BACKGROUND We investigated the influence of the body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]) on the frequency, severity, and patterns of treatment of migraine, probable migraine (PM), and severe episodic tension-type headache (S-ETTH). METHODS A validated questionnaire was mailed to 120 000 households(More)