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Family relationships across 3 groups of adolescents were compared: (a) those with unipolar depressive disorders (n=82); (b) those with subdiagnostic depressive symptoms (n=78); and (c) those without emotional or behavioral difficulties (n=83). Results based on multisource, multimethod constructs indicated that depressed adolescents, as well as those with(More)
Data collected from 294 young adults, ages 19 to 25, and both a same- and an opposite-gender best friend or mate across 3 annual assessments were analyzed to examine the similarity to and influence of the peer on the young adult's substance use. The authors found similarity across time between both peers and the young adult in cigarette use, alcohol use,(More)
Genome-wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting of at least two ever smokers (100 or more cigarettes smoked in lifetime). DNA from whole blood was genotyped for 739 autosomal microsatellite polymorphisms with an average inter-marker distance of 4.6 cM.(More)
This study reports on the social problem-solving interactions of young adolescents in single-parent and intact families on substance-specific and nonsubstance-related issues. Although research has shown the impact of families on adolescent substance use, all of the previous results have been based on questionnaire or interview data. A sample of 128 families(More)
This study describes the lifetime prevalence and future intentions related to trying cigarettes, chewing tobacco, alcohol, marijuana, and inhalants of students in the 1st through 7th grade. This article also describes the identification of these substances by children in the 1st through 3rd grade. Participants were 1,075 1st through 5th graders within a(More)
We utilized a cohort of 828 treatment-seeking self-identified white cigarette smokers (50% female) to rank candidate gene single nucleotide polymorphisms (SNPs) associated with the Fagerström Test for Nicotine Dependence (FTND), a measure of nicotine dependence which assesses quantity of cigarettes smoked and time- and place-dependent characteristics of the(More)
Characterizing cotinine pharmacokinetics is a useful way to study nicotine metabolism because the same liver enzyme is primarily responsible for the metabolism of both, and the clearances of nicotine and cotinine are highly correlated. We conducted a whole-genome linkage analysis to search for candidate regions influencing quantitative variation in cotinine(More)
The purpose of this study was to explore the relations between child responses to interparental depressive behavior and subsequent child depressive symptomatology. Data were collected on 156 two-parent families. Families completed questionnaire data and participated in problem-solving interactions, which were coded using a microsocial observational system.(More)
This project studied the convergent validity of current recall of tobacco-related health behaviors, compared with prospective self-report collected earlier at two sites. Cohorts were from the Oregon Research Institute at Eugene (N = 346, collected 19.5 years earlier) and the University of Pittsburgh, Pennsylvania (N = 294, collected 3.9 years earlier).(More)
The present study correlates empirically constructed prospective adolescent smoking trajectories with indicators of nicotine dependence assessed in adolescence and in adulthood. Excluding individuals who reported no smoking during repeat assessment (nonadopters), we identified five smoking trajectory groups: experimenters (n=116, 48.5%), late increasers(More)