Elizabeth S. Fleming

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A major feature of epithelial cell polarity is regulated positioning of the mitotic spindle within the cell. Spindles in cells of symmetrically expanding tissues are predicted to align parallel to the tissue plane. Direct measurement of this alignment has been difficult in mammalian tissues. Here, we analyzed the position of spindles in intact mouse(More)
After fertilization, maternal factors direct development and trigger zygotic genome activation (ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for gastrulation and clearance of maternal messenger RNAs, which is in part regulated by the conserved microRNA miR-430. However, the factors that activate the zygotic program in(More)
The Traffic alert and Collision Avoidance System (TCAS) is often framed as separate to-or opposing-air traffic control, i.e. as a backup, redundant system that invokes resolution advisories (RAs) when all other methods of separation assurance fail. A flight simulator experiment examined pilot interaction with TCAS in the context of a full air traffic(More)
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