Elizabeth S. Draper

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BACKGROUND Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother's intake but also by genetic variants carried by both(More)
OBJECTIVE To determine survival and neonatal morbidity for babies born between 22 and 26 weeks' gestation in England during 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN Prospective national cohort studies. SETTING Maternity and neonatal units in England. PARTICIPANTS 3133 births between(More)
OBJECTIVE To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN Prospective national cohort studies, EPICure and EPICure 2. SETTING Hospital and home based evaluations, England. PARTICIPANTS 1031(More)
STUDY QUESTION What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid fortification of food does not exist? (More)
BACKGROUND There is substantial debate as to whether moderate alcohol use during pregnancy could have subtle but important effects on offspring, by impairing later cognitive function and thus school performance. The authors aimed to investigate the unconfounded effect of moderately increased prenatal alcohol exposure on cognitive/educational performance. (More)
OBJECTIVE To describe one year outcomes for a national cohort of infants with gastroschisis. DESIGN Population based cohort study of all liveborn infants with gastroschisis born in the United Kingdom and Ireland from October 2006 to March 2008. SETTING All 28 paediatric surgical centres in the UK and Ireland. PARTICIPANTS 301 infants (77%) from an(More)
OBJECTIVES To investigate socioeconomic inequalities in outcome of pregnancy and neonatal mortality associated with congenital anomalies. DESIGN Retrospective population based registry study. SETTING East Midlands and South Yorkshire regions of England (representing about 10% of births in England and Wales). PARTICIPANTS All registered cases of nine(More)
OBJECTIVE To investigate whether light drinking in pregnancy is associated with adverse child mental health and academic outcomes. DESIGN Using data from the prospective, population-based Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the associations between light drinking in pregnancy (<1 glass per week in the first trimester)(More)
OBJECTIVE To investigate time trends in socioeconomic inequalities in cause specific neonatal mortality in order to assess changing patterns in mortality due to different causes, particularly prematurity, and identify key areas of focus for future intervention strategies. DESIGN Retrospective cohort study. SETTING England. PARTICIPANTS All neonatal(More)
OBJECTIVES To assess the prevalence of positive screens using the Modified Checklist for Autism in Toddlers (M-CHAT) questionnaire and follow-up interview in late and moderately preterm (LMPT; 32-36 weeks) infants and term-born controls. STUDY DESIGN Population-based prospective cohort study of 1130 LMPT and 1255 term-born infants. Parents completed the(More)