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OBJECTIVE To determine survival and neonatal morbidity for babies born between 22 and 26 weeks' gestation in England during 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN Prospective national cohort studies. SETTING Maternity and neonatal units in England. PARTICIPANTS 3133 births between(More)
BACKGROUND Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother's intake but also by genetic variants carried by both(More)
BACKGROUND Infants born preterm are at increased risk of adverse health and developmental outcomes. Mortality and morbidity after preterm birth impose a burden on finite public sector resources. This study considers the economic consequences of preterm birth from birth to adult life and compares the costs accruing to those born preterm with those born at(More)
OBJECTIVE To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN Prospective national cohort studies, EPICure and EPICure 2. SETTING Hospital and home based evaluations, England. PARTICIPANTS 1031(More)
INTRODUCTION Published prevalence rates of congenital diaphragmatic hernia (CDH) vary. This study aims to describe the epidemiology of CDH using data from high-quality, population-based registers belonging to the European Surveillance of Congenital Anomalies (EUROCAT). METHODS Cases of CDH delivered between 1980 and 2009 notified to 31 EUROCAT registers(More)
OBJECTIVE To assess changes in survival for infants born before 26 completed weeks of gestation. DESIGN Prospective cohort study in a geographically defined population. SETTING Former Trent health region of the United Kingdom. SUBJECTS All infants born at 22+0 to 25+6 weeks' gestation to mothers living in the region. Terminations were excluded but all(More)
BACKGROUND Adverse cognitive and educational outcomes are often ascribed to perinatal hypoxia without good evidence. OBJECTIVE To investigate neurocognitive and behavioural outcomes after neonatal encephalopathy. METHODS Sixty five children with neonatal encephalopathy, identified using the Trent Neonatal Survey database for 1992-1994, were followed up(More)
OBJECTIVE To provide current population-based prevalence and prenatal diagnosis rates (PND) for specified major congenital anomalies in England and Wales to enable monitoring of the Fetal Anomaly Screening Programme (FASP). DESIGN Secondary analysis of prospectively collected registry data. SETTING Seven multiple-source, population-based congenital(More)
The aim of this study was to examine the prevalence of trisomies 18 and 13 in Europe and the prevalence of associated anomalies. Twenty-five population-based registries in 16 European countries provided data from 2000-2011. Cases included live births, fetal deaths (20+ weeks' gestation), and terminations of pregnancy for fetal anomaly (TOPFAs). The(More)
OBJECTIVES To establish precise incidence figures for trisomy 13 and trisomy 18 in the former Trent region, to identify current prenatal diagnostic practice, and to assess the potential impact of the introduction of recently devised prenatal diagnostic practices. METHODS An audit of all cases of trisomy 13 and trisomy 18 ascertained through the records of(More)