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We have identified a Y-chromosomal lineage with several unusual features. It was found in 16 populations throughout a large region of Asia, stretching from the Pacific to the Caspian Sea, and was present at high frequency: approximately 8% of the men in this region carry it, and it thus makes up approximately 0.5% of the world total. The pattern of(More)
OBJECTIVE To assess the long term effectiveness of the "green prescription" programme, a clinician based initiative in general practice that provides counselling on physical activity. DESIGN Cluster randomised controlled trial. Practices were randomised before systematic screening and recruitment of patients. SETTING 42 rural and urban general practices(More)
OBJECTIVE Magnetic resonance imaging (MRI) is capable of revealing synovitis and tendinitis in early rheumatoid arthritis (RA), as well as bone edema and erosion. These features are visible before radiographic joint damage occurs. We sought to examine whether MRI of one body region (the wrist) can be used to predict whole-body radiography scores reflecting(More)
OBJECTIVES To estimate the contribution of driver sleepiness to the causes of car crash injuries. DESIGN Population based case control study. SETTING Auckland region of New Zealand, April 1998 to July 1999. PARTICIPANTS 571 car drivers involved in crashes where at least one occupant was admitted to hospital or killed ("injury crash"); 588 car drivers(More)
BACKGROUND The prevalence of atopic dermatitis (AD) is increasing in Western societies. The hygiene hypothesis proposes that this is due to reduced exposure to environmental allergens and infections during early life. OBJECTIVES To examine factors associated with a diagnosis of AD at 3.5 years of age, especially those factors implicated by the hygiene(More)
OBJECTIVE To describe the sexual attractions of New Zealand secondary school students and investigate the associations between sexual attraction and self-reported depression, self-harm, suicidality and help-seeking behaviour. METHOD Multiple logistic regression was used to examine the associations between sexual attraction and depressive symptoms,(More)
PURPOSE To identify declines in physical functioning, directly attributable to the effects of hip fracture. METHODS A follow-up study of participants in a case-control study was conducted in Auckland, New Zealand, between 1993 and 1996. Nine hundred and eleven randomly selected older people with a hip fracture at the time of the initial interview (cases)(More)
OBJECTIVES To develop and test an MRI cartilage scoring system for use at the wrist in rheumatoid arthritis (RA). METHODS MRI scans were obtained using a 3T MRI scanner with dedicated wrist coil in 22 early and 16 established RA patients plus 22 controls. Axial and coronal T1-weighted (precontrast and postcontrast) and T2-weighted turbo spin echo(More)
BACKGROUND Term infants who are small for gestational age appear prone to the development of insulin resistance during childhood. We hypothesized that insulin resistance, a marker of type 2 diabetes mellitus, would be prevalent among children who had been born prematurely, irrespective of whether they were appropriate for gestational age or small for(More)
PURPOSE We wanted to assess the effectiveness of a home-based physical activity program, the Depression in Late Life Intervention Trial of Exercise (DeLLITE), in improving function, quality of life, and mood in older people with depressive symptoms. METHODS We undertook a randomized controlled trial involving 193 people aged 75 years and older with(More)