Clinical cancer research : an official journal of…
Zebularine is a DNA methyltransferase inhibitor proposed for clinical evaluation.
We developed a liquid chromatography/mass spectrometry assay and did i.v. and oral studies in mice, rats, and rhesus monkeys.
In mice, plasma zebularine concentrations declined with terminal half-lives (t(1/2)) of 40 and 91 minutes after… (More)