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Contemporary perspectives on age differences in risk taking, informed by advances in developmental neuroscience, have emphasized the need to examine the ways in which emotional and cognitive factors interact to influence decision making. In the present study, a diverse sample of 901 individuals between the ages of 10 and 30 were administered a modified(More)
It has been proposed that high rates of risk-taking in adolescence are partly attributable to patterns of neurobiological development that promote an increase in sensation-seeking tendencies at a time when impulse control is still developing. It is not known, however, whether this pattern is the same for males and females. The present study investigates sex(More)
Anticancer vaccine strategies can now target intracellular antigens that are involved in the process of malignant transformation, such as oncogene products or mutated tumor suppressor genes. Fragments of these antigens, generally 8-10 amino acids in length and complexed with MHC class I molecules, can be recognized by CD8+ T lymphocytes (TCD8+). To explore(More)
The present study examines the associations between coping efforts and psychological (internalizing and externalizing symptoms) and behavioral adjustment in a sample of 373 male juvenile offenders (ages 14-17) during the first month of incarceration. Social support seeking was associated with a more rapid decline in internalizing symptoms and lower levels(More)
BACKGROUND The identification of tumor-associated antigens and the cloning of DNA sequences encoding them have enabled the development of anticancer vaccines. Such vaccines target tumors by stimulating an immune response against the antigens. One method of vaccination involves the delivery of antigen-encoding DNA sequences, and a number of recombinant(More)
What is the orientation of an object? A simple line has an axis of orientation. That line, turned upside-down, is indistinguishable from the original line. Thus, the possible orientations of a line range from 0 to 180 degrees. Most objects, however, have an axis and a polarity. A polar object, turned upside-down, looks upside-down. Accordingly, the(More)
To study the induction of anti-"self" CD8+ T-cell reactivity against the tumor antigen gp100, we used a mouse transgenic for a chimeric HLA-A*0201/H-2 Kb molecule (A2/Kb). We immunized the mice with a recombinant vaccinia virus encoding a form of gp100 that had been modified at position 210 (from a threonine to a methionine) to increase epitope binding to(More)
Directed forgetting research shows that people can inhibit the retrieval of words that they were previously instructed to forget. The present research applied the directed forgetting procedure to the Deese/Roediger and McDermott (DRM) recall task to determine if directed forgetting instructions have similar or different effects on accurate and false memory.(More)
The present study investigates the relation between moral disengagement-one's willingness to conditionally endorse transgressive behavior-and ongoing offending in a sample of adolescent male felony offenders (N = 1,169). In addition, the study attempts to rule out callous-unemotional traits as a third variable responsible for observed associations between(More)
Elevated levels of risky behavior in adolescence may signal developmental change in unconscious appraisal of risk. Yet, prior research examining adolescent risk judgment has used tasks that elicit conscious deliberation. The present study, in contrast, attempts to characterize age differences in (less conscious) intuitive impressions of risk. Participants(More)