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Here, we describe a novel mechanism for the rapid regulation of surface levels of the neurotrophin receptor TrkB. Unlike nodose ganglion neurons, both retinal ganglion cells (RGCs) and spinal motor neurons (SMNs) in culture display only low levels of surface TrkB, though high levels are present intracellularly. Within minutes of depolarization or cAMP(More)
•We describe two cases of villoglandular adenocarcinoma and review the literature.•This subtype may be treated more conservatively but few papers have described this.•Conservative management may be preferable for women who desire fertility.•Our experience shows successful treatment of VGA with CKC and simple hysterectomy.
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