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Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring (MRM) to study biological and biomedical questions is well underway in the proteomics community. Successful application depends on the ability to generate reliable assays that uniquely and confidently identify target peptides in a sample. Unfortunately, there is a(More)
Group-based moving frames have a wide range of applications, from the classical equivalence problems in differential geometry to more modern applications such as computer vision. Here we describe what we call a discrete group-based moving frame, which is essentially a sequence of moving frames with overlapping domains. We demonstrate a small set of(More)
We study variational problems for curves approximated by B-spline curves. We show that one can obtain discrete Euler-Lagrange equations for the data describing the approximated curves. Our main application is to the occluded curve problem in 2D and 3D. In this case, the aim is to find various aesthetically pleasing solutions as opposed to a solution of a(More)
1 Summary This meeting focused on geometrical approximation techniques and symbolic algorithms for differential equations with a particular focus on symbolic invariant calculus and discrete invariant calculus. A key goal of the meeting was to bring together researchers working at the intersection of the above areas; and highlight open problems in the(More)
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