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Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist

• William R. Kelce, Christy R. Stone, Susan C Laws, Leon Earl Gray, Jon A. Kemppainen, Elizabeth M. Wilson
• Nature
• 1995

THE increase in the number of reports of abnormalities in male sex development in wildlife and humans coincided with the introduction of 'oestrogenic' chemicals such as DDT… (More)

Androgen receptor defects: historical, clinical, and molecular perspectives.

• Charmian A. Quigley, A de Bellis, Keith B. Marschke, Mustafa K El-Awady, Elizabeth M. Wilson, Frank S. French
• Endocrine reviews
• 1995

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

• Albert R. La Spada, Elizabeth M. Wilson, Dennis B. Lubahn, Anita E. Harding, Kenneth H. Fischbeck
• Nature
• 1991

X-LINKED spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated… (More)

FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor.

• Bin He, Jon A. Kemppainen, Elizabeth M. Wilson
• The Journal of biological chemistry
• 2000

The nuclear receptor superfamily members of eukaryotic transcriptional regulators contain a highly conserved activation function 2 (AF2) in the hormone binding carboxyl-terminal domain and, for some,… (More)

Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.

• Suxia Bai, Bin He, Elizabeth M. Wilson
• Molecular and cellular biology
• 2005

Gene activation by steroid hormone receptors involves the recruitment of the steroid receptor coactivator (SRC)/p160 coactivator LXXLL motifs to activation function 2 (AF2) in the ligand binding… (More)

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

• Jon A. Kemppainen, Malcolm Lane, Madhabananda Sar, Elizabeth M. Wilson
• The Journal of biological chemistry
• 1992

Nuclear transport, phosphorylation, ligand binding, and degradation rate of the recombinant androgen receptor (AR) were analyzed in transfected COS cells in the presence of various steroids and… (More)

Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity.

• Elizabeth Langley, Jon A. Kemppainen, Elizabeth M. Wilson
• The Journal of biological chemistry
• 1998

Structural alignment of the human androgen receptor dimer was investigated by introducing steroid binding domain mutations that cause partial or complete androgen insensitivity into fusion proteins… (More)

Cloning of human androgen receptor complementary DNA and localization to the X chromosome.

• Dennis B. Lubahn, David R. Joseph, Patrick M Sullivan, Huntington F. Willard, Frank S. French, Elizabeth M. Wilson
• Science
• 1988

The androgen receptor (AR) mediates the actions of male sex steroids. Human AR genomic DNA was cloned from a flow-sorted human X chromosome library by using a consensus nucleotide sequence from the… (More)

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.

• Hyun Sook Kim, Srivinasa R Nagalla, Y. L. Oh, Elizabeth M. Wilson, Charles Roberts, Ron G. Rosenfeld
• Proceedings of the National Academy of Sciences…
• 1997

The insulin-like growth factor (IGF) binding proteins (IGFBPs) modulate the actions of the insulin-like growth factors in endocrine, paracrine, and autocrine settings. Additionally, some IGFBPs… (More)

The androgen axis in recurrent prostate cancer.

• James L. Mohler, Christopher W. Gregory, +5 authors Frank S. French
• Clinical cancer research : an official journal of…
• 2004

PURPOSE Prostate cancer that recurs during androgen deprivation therapy is referred to as androgen-independent. High levels of expression of androgen receptor and androgen receptor-regulated genes in… (More)

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