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Ten chemicals were assessed for blastomogenic activity in adult wts/+ heterozygotes of D. melanogaster. All of the strong mammalian carcinogens tested (benzo(a)pyrene (B(a)P), pyrene, aflatoxin B(1), 2-acetylaminofluorene (2-AAF) and cis-dichlorodihydroxydiamminoplatinum IV) were also shown to be strong Drosophila blastomogens. They induced several times(More)
Thegenotoxic activity of four mycotoxins has been studied. A high level of somatic mutagenesis in imaginal disks of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures was induced only by the strong carcinogen aflatoxin B1. Patulin somewhat elevated the level of somatic mutations in D. melanogaster, but(More)
Mutagenic and carcinogenic properties of mildronate (3-[2.2.2.-trimethyl hydrazonium]-propionate) have been studied for its marked immuno-stimulating and anti-ischemic action. When dosage up to 1,000 mg/dish was used no reversal of base-pair substitution or frame shift in S.typhimurium was observed. In drosophila females treated with mildronate, mosaic(More)
The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction inE. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) theSalmonella/microsome assay, (iv) a host-mediated assay usingSalmonella, (v) the somatic mutation and recombination assay inDrosophila melanogaster, (vi)(More)
The genotoxic activity of four mycotoxins has been studied. High level of somatic mutagenesis in imaginal discs of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures were inducible only by highly carcinogenic aflatoxin B1. Patulin, a weak direct-action carcinogenic substance, slightly elevated the(More)
In an experiment with black guinea pigs a phenocopy of vitiligo was obtained by means of the exposure of the skin to the action of p-tert-butyl-phenol (PTBP) or to catechol (C). Two other compounds: 2,2-dihydroxy-diphenylpropane (DDP) and 2, 4, 6-tri-tert-butyl-phenol (TTBP) exerted a hypopigmentary effect. PTBP and C depigmented the skin but caused no(More)
The basic condition for the toxic, mutagenic, and carcinogenic action of polycyclic aromatic hydrocarbons (PAH) and aromatic amines (AA) on mammalian cells is their activation to proximal highly mutagenic metabolites in the system of microsomal monooxygenases by a special isoform of cytochrome P-450, induced by these metabolites [2]. Unlike in mammals, in(More)
The genotoxic p r o p e r t i e s of chemical ca rc inogens a re nowadays being brought to light at an increas ing ra te . In jur ies to the DNA and mutat ions in var ious s y s t e m s a re used by 85-90% of carcinogenic polycycl ic hydroca rbons , n i t roso compounds, and other agents [9]. So f a r as the carc inogenic mycotoxins a r e concerned, the r e(More)
A 364 yv strain sensitive to the toxic effect of benzo(a)pyrene (BP) was identified among 49 mutant strains of Drosophila simulans. Heterozygotes female 364 x male Turku obtained by crossing 364 yv species with those of wild BP-resistant Turku strain were more sensitive than female Turku x male 364 heterozygotes to both toxic and mutagenic effects of the(More)