Learn More
In this paper, we describe DyRecT (Dynamic Reconfigu-ration Toolkit) a software library that allows programmers to develop adaptively parallel message-passing MPI programs for clusters of workstations. DyRecT provides a high-level API that can be used for writing adaptive parallel HPF-like programs while hiding most of the details of the dynamic(More)
A concurrent software application, whether running on a single machine or distributed across multiple machines, is composed of tasks that interact (communicate and sychronize) in order to achieve some goal. Developing such concurrent programs so they cooperate effectively is a complex task, requiring that progrmmers craft their modules–the components(More)
Tuberculosis treatments need to be shorter and overcome drug resistance. Our previous large scale phenotypic high-throughput screening against Mycobacterium tuberculosis (Mtb) has identified 737 active compounds and thousands that are inactive. We have used this data for building computational models as an approach to minimize the number of compounds(More)
Clusters of workstations are increasingly being viewed as a cost-eeective alternative to parallel su-percomputers. However, resource management and scheduling on workstations clusters is complicated by the fact that the number of idle workstations available for executing parallel applications is constantly uctu-ating. In this paper, we present a case for(More)
The most important aspect of concurrent and distributed computation is the interaction between system components. Integration of components into a system requires some synchronization that prevents the components from interacting in ways that may endanger the system users, its correctness or performance. The undesirable interactions are usually described(More)
Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of tubulin, FtsZ. Initial screening of 200 2-alkoxycarbonylpyridines found several that inhibited M. tuberculosis growth. Two compounds, SRI-3072 and SRI-7614, inhibited FtsZ polymerization and were(More)
The gene for dihydrofolate reductase of Mycobacterium tuberculosis was amplified by polymerase chain reaction (PCR) from M. tuberculosis H37Rv strain genomic DNA. The protein was expressed in inclusion bodies in high yield in Escherichia coli under the control of the T7 promoter. Active enzyme was obtained by refolding from guanidine HCl and after a single(More)
Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 million children under five years of age are affected by hRSV resulting in three million hospitalizations and 200,000 deaths. However, severe lower(More)