Elizabeth L. Virts

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Fanconi anemia (FA) is a rare inherited disorder clinically characterized by congenital malformations, progressive bone marrow failure and cancer susceptibility. At the cellular level, FA is associated with hypersensitivity to DNA-crosslinking genotoxins. Eight of 17 known FA genes assemble the FA E3 ligase complex, which catalyzes monoubiquitination of(More)
The anaphylatoxin C5a is an especially potent mediator of both local and systemic inflammation. However, C5a also plays an essential role in mucosal host defense against bacterial, viral, and fungal infection. We have developed a response-selective agonist of human C5a, termed EP67, which retains the immunoenhancing activity of C5a at the expense of its(More)
Acute myeloid leukemia (AML) continues to be a difficult-to-treat disease with a high relapse rate, and individuals presenting with FLT3-ITD+ status exhibit a poor prognosis 1. We demonstrated previously that genetic disruption or pharmacologic inhibition of the protein tyrosine phosphatase, Shp2, reduced FLT3-ITD-induced STAT5 hyperactivation,(More)
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