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Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.

• Andrew R. Stiff, Prashant Trikha, +21 authors William E. Carson
• Cancer research
• 2016

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC… (More)

MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions.

• Amanda R. Campbell, Megan C. Duggan, +17 authors William E. Carson
• Cancer immunology research
• 2017

Natural killer (NK) cells are large granular lymphocytes that promote the antitumor response via communication with other cell types in the tumor microenvironment. Previously, we have shown that NK… (More)

Targeting tissue factor as a novel therapeutic oncotarget for eradication of cancer stem cells isolated from tumor cell lines, tumor xenografts and patients of breast, lung and ovarian cancer

• Zhiwei Hu, Jie Xu, Jijun Cheng, Elizabeth L McMichael, Lianbo Yu, William E. Carson
• Oncotarget
• 2017

Targeting cancer stem cell (CSC) represents a promising therapeutic approach as it can potentially fight cancer at its root. The challenge is to identify a surface therapeutic oncotarget on CSC.… (More)

Kinetics and thermodynamics of DNA, RNA, and hybrid duplex formation.

• Brittany Rauzan, Elizabeth L McMichael, +7 authors Alice A Deckert
• Biochemistry
• 2013

The rates of duplex formation for two octamers of DNA (5' d-CACGGCTC/5' d-GAGCCGTG and 5' d-CACAGCAC/5' d-GTGCTGTG), the homologous RNA, and both sets of hybrids in 1 M NaCl buffer have been measured… (More)

IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells.

• Elizabeth L McMichael, Alena Cristina Jaime-Ramirez, +13 authors William E. Carson
• Clinical cancer research : an official journal of…
• 2017

PURPOSE Alternative strategies to EGFR blockage by mAbs is necessary to improve the efficacy of therapy in patients with locally advanced or metastatic pancreatic cancer. One such strategy includes… (More)

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function.

• Andrew R. Stiff, Prashant Trikha, +21 authors William E. Carson
• Clinical cancer research : an official journal of…
• 2018

Purpose: mAbs are used to treat solid and hematologic malignancies and work in part through Fc receptors (FcRs) on natural killer cells (NK). However, FcR-mediated functions of NK cells from patients… (More)

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25.

• Megan C. Duggan, Amanda R. Campbell, +7 authors William E. Carson
• Oncoimmunology
• 2018

Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in… (More)

Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells.

• Kavin Fatehchand, Elizabeth L McMichael, +15 authors Susheela Tridandapani
• The Journal of biological chemistry
• 2016

Acute myeloid leukemia (AML) is characterized by the proliferation of immature myeloid lineage blasts. Due to its heterogeneity and to the high rate of acquired drug resistance and relapse, new… (More)

Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells

• Elizabeth L McMichael, Alena Cristin Jaime-Ramirez, Kristan D Guenterberg, Eric A. Luedke, Lakhvir S Atwal, William E. Carson
• 2015

Natural killer (NK) cells are large granular lymphocytes that play a critical role in anti-cancer mechanisms. These effector cells mediate antibody-dependent cellular cytotoxicity (ADCC) and produce… (More)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

• Sonja Althammer, Keith Steele, +417 authors John D. Powderly
• 2016

4501. Coinhibition & Costimulation O4 Computational identification, functional characterization, and antibody blockade of a new immune checkpoint in the TIGIT family of interacting molecules Ofer… (More)

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