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Gut granules are specialized lysosome-related organelles that act as sites of fat storage in Caenorhabditis elegans intestinal cells. We identified mutations in a gene, glo-3, that functions in the formation of embryonic gut granules. Some glo-3(-) alleles displayed a complete loss of embryonic gut granules, while other glo-3(-) alleles had reduced numbers(More)
Caenorhabditis elegans gut granules are intestine specific lysosome-related organelles with birefringent and autofluorescent contents. We identified pgp-2, which encodes an ABC transporter, in screens for genes required for the proper formation of gut granules. pgp-2(-) embryos mislocalize birefringent material into the intestinal lumen and are lacking in(More)
The human disease Hermansky-Pudlak syndrome results from defective biogenesis of lysosome-related organelles (LROs) and can be caused by mutations in subunits of the BLOC-1 complex. Here we show that C. elegans glo-2 and snpn-1, despite relatively low levels of amino acid identity, encode Pallidin and Snapin BLOC-1 subunit homologues, respectively. BLOC-1(More)
A retrospective cohort study and chart review were performed to estimate the absolute and relative prevalence of the serious diagnoses that might cause a patient to present to the Emergency Department (ED) with a chief complaint of chest pain. In this study, we queried a database of 347,229 complete visits to the San Francisco General Hospital Emergency(More)
Social networks, which have become extremely popular in the twenty first century, contain a tremendous amount of user-generated content about real-world events. This user-generated content relays real-world events as they happen, and sometimes even ahead of the newswire. The goal of this work is to identify events from social streams. The proposed model(More)
BACKGROUND Survey data over the last several decades suggests that emergency department (ED) access to diagnostic ultrasound performed by the radiology department is unreliable, particularly outside of regular business hours. OBJECTIVE To evaluate the association between the time of day of patient presentation and the use of diagnostic ultrasound services(More)
It has always seemed to me that the writers of the American Constitution are remembered and honoured to a much greater extent than we honour their Australian counterparts. There are of course some Canberra suburbs and a few House of Representatives electorates that bear the names of our constitutional founders, but most of them are largely forgotten. The(More)
Social networks, which have become extremely popular nowadays, contain a tremendous amount of user-generated content about real-world events. This user-generated content can naturally reflect the real-world event as they happen, and sometimes even ahead of the newswire. The goal of this work is to identify events from social streams. A model called(More)
The purpose of this project was to determine the current climate conditions of the Volvo plant located in Dublin, Virginia. Since no air conditioning was installed in the plant the employees become uncomfortable while they work. Fans were located sporadically around the plant to alleviate this problem. Critical areas within the plant needed to be identified(More)
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