Elizabeth K Torres

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The neonatal Fc receptor (FcRn) plays an important and well-known role in antibody recycling in endothelial and hematopoietic cells and thus it influences the systemic pharmacokinetics (PK) of immunoglobulin G (IgG). However, considerably less is known about FcRn's role in the metabolism of IgG within individual tissues after intravenous administration. To(More)
Advances in monoclonal antibody (mAb) engineering, including phage-display technologies, have enabled the development of humanized, i.e., mouse complementarity determining region (CDR) residues grafted on to a human framework residues, as well as fully human antibodies with desirable pharmacokinetic (PK) and biodistribution properties. These engineered mAbs(More)
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