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Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies
TLDR
The global burden of fungal infections, the reservoirs of these pathogens, the traits of opportunistic yeast that lead to pathogenesis, host genetic susceptibilities, and the challenges that must be overcome to combat antifungal drug resistance and improve clinical outcome are reviewed.
Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen
TLDR
A global view of the Hsp90 interactome in a fungal pathogen is provided, the dynamic role of HSp90 in response to environmental perturbations is demonstrated, and a novel connection between Hsp 90 and the regulation of mRNA-associated protein granules is highlighted.
Elucidating drug resistance in human fungal pathogens.
TLDR
Development of novel strategies to block the emergence of drug resistance and render resistant pathogens responsive to antifungals will be critical to treating life-threatening fungal infections.
Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress
TLDR
This work uncovers novel circuitry regulating Hsp90 functional capacity and new effectors governing drug resistance, morphogenesis and virulence, revealing new targets for antifungal drug development.
DNA sequence elements required for partitioning competence of the Saccharomyces cerevisiae 2-micron plasmid STB locus
TLDR
The identification of sequence motifs required for Rep protein recognition provides the basis for understanding higher-order Rep protein arrangements at STB that enable the yeast 2-micron plasmid to be efficiently partitioned during host cell division.
Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis
TLDR
A new mechanism by which metal chelation modulates morphogenetic circuitry and echinocandin resistance is established, and a novel facet to metal homeostasis at the host-pathogen interface is illuminated, with broad therapeutic potential.
Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A
TLDR
Staurosporine is established as a chemical probe to elucidate the architecture of cellular signaling governing fungal morphogenesis and highlight the existence of novel circuitry through which the Cyr1 and PKA govern a key virulence trait.
Functional divergence of a global regulatory complex governing fungal filamentation
TLDR
This work highlights rewiring of key morphogenetic regulators over evolutionary time and aneuploidy as an adaptive mechanism driving fungal morphogenesis.
Structure-guided approaches to targeting stress responses in human fungal pathogens
TLDR
Progress is focused on the progress that has been made with highly conserved regulators, including the molecular chaperone Hsp90, the protein phosphatase calcineurin, and the small GTPase Ras1, as well as with divergent stress response regulators,including the cell wall kinase Yck2 and trehalose synthases.
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