Elizabeth Hewitt

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Withdrawal responses to mechanical and thermal stimuli applied to the plantar surface of the hindpaw were measured before and after bone damage. In separate groups of rats the bone was injured by scraping the periosteum of the tibia, drilling a hole through the tibia, aspirating bone marrow, or drilling a hole through the calcaneus. Scraping the periosteum(More)
The intestinal helminth Oesophagostomum bifurcum is highly and focally endemic in northern Ghana and Togo, and its juveniles produce a nodular inflammatory response as they develop in the intestinal wall. This pathology can produce clinical symptoms. We report on 156 cases of oesophagostomiasis presenting in 1996-98 to Nalerigu hospital in northern Ghana.(More)
Intradermally transplanted non-immunogenic murine carcinomas measuring 3-6 mm in diameter were exposed to a neodymium-YAG laser beam (1060 nm) over a range of exposure times (0.5-6 seconds) and energy densities (expressed as watts/mm2 exposure field). Subsequent growth of the irradiated tumours was compared with that of untreated tumours. A clear(More)
Inflammation is a well-established contributor to numerous medical conditions, and has discrete roles in disease processes ranging from coronary artery disease and end-stage renal disease to both acute and chronic pain conditions. In some disease processes, inflammatory biomarkers are used clinically to track disease progression and efficacy of treatment,(More)
Withdrawal reflex responses to graded von Frey filaments applied to the plantar surface of the paw were measured before and after bone hole damage in rats with either a dorsal column (DC) lesion or a sham DC lesion. Two methods were employed to produce models of osteotomy; a small hole was drilled through either the (1) tibia or (2) calcaneus (Houghton,(More)
A novel reversed-phase ultra high performance liquid chromatography coupled with high resolution quantitation mass spectrometry (UHPLC/HRQMS) method was developed to quantify 2,5-dichlorobenzoyl chloride (DCBC), a genotoxic impurity, in MLN9708 drug substance. A surrogate strategy was utilized whereby DCBC was intentionally hydrolyzed to 2,5-dichlorobenzoic(More)
A punctate midline myelotomy performed in a patient effectively eliminated residual, intractable pelvic pain, which remained after resolution of uterine cervical cancer. The authors describe the case history of the patient, in whom pain assessments were made, and a surgical procedure performed. Despite large doses of opiate analgesic medications, the(More)
Oesophagostomiasis is an infrequently described and recognised parasitic infection in humans, caused by Oesophagostomum bifurcum. Although the disease is most often found in the northern part of Togo and the neighbouring part of Ghana, sporadic cases have been described in other parts of Africa and in Asia and South America: Uganda, Ivory Coast, Sudan,(More)
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