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This Phase 2 study evaluated the safety and efficacy of elagolix for treating endometriosis-associated pain. A total of 155 women with laparoscopically confirmed endometriosis were randomized to placebo, elagolix 150 mg, or elagolix 250 mg once daily for 12 weeks. Placebo patients were rerandomized to elagolix and elagolix patients continued their dosing(More)
Routine acceptance of use of hormone replacement therapy (HRT) was shattered in 2002 when results of the largest HRT randomised clinical trial, the women's health initiative, indicated that long term use of oestrogen plus progestin HRT not only was associated with increased risk of cancer but, contrary to expectations, did not decrease, and may have(More)
Nasal carriage of Staphylococcus aureus is a sensitive indicator of staphylococcal col-onization and is considered a source of subsequent infection. When the incidence of S. au-reus colonization increased in our neonatal intensive care unit (NICU), resulting in three methicillin-resistant Staphylococcus aureus (MRSA) infections over a three-month period, we(More)
This randomized double-blind study, with 24-week treatment and 24-week posttreatment periods, evaluated the effects of elagolix (150 mg every day, 75 mg twice a day) versus subcutaneous depot medroxyprogesterone acetate (DMPA-SC) on bone mineral density (BMD), in women with endometriosis-associated pain (n = 252). All treatments induced minimal mean changes(More)
It was hypothesized white-tailed deer {Odocoileus virginianus) could be readily conditioned to 2 commonly used deterrents, Deer-Away® Big Game Repellent (BGR) and blood meal (BM). Plots were randomly assigned BGR, BM and control. Free-ranging deer were initially conditioned to forage for corn at each 49m bare earth plots delivered at 0500 hr and 1600 hr by(More)
diagnostic skin tests. All parasites may not necessarily produce as intense or as long-lasting an immediate hypersen-sitivity as does T. canis (Wiseman and Woodruff, 1970), and any trial of an antigen in subjects with different known infections should preferably include a direct comparison with their response to homologous antigen. This sesponse cannot be(More)
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