Elizabeth Ezra

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Gonadotropin induced desensitization of adenylate cyclase (AC) in purified rat ovarian plasma membrane preparations requires a 40 min preincubation period with that same hormone and guanosine triphosphate (GTP). This phenomenon can be demonstrated for the response of AC to luteinizing hormone (LH), follicle stimulating hormone (FSH) and human chorionic(More)
Activity of adenylate cyclase [(EC ATP pyrophosphate lyase (cyclizing)] in purified rat ovarian plasma membranes undergoes partial desensitization (30-60%) upon exposure to saturating lutropin (LH, 0.1 p ~ ) and GTP (1 p ~ ) . Decline in hormone responsiveness of the enzyme is dose-dependent with regard to LH ( K , = 1.7 IWI +. 1) and GTP ( K , =(More)
Incubation of purified rat brain tubulin with cholera toxin and radiolabeled [32P] or [8-3H]NAD results in the labeling of both alpha and beta subunits as revealed on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Treatment of these protein bands with snake venom phosphodiesterase resulted in quantitative release of labeled 5'-AMP,(More)
Lutropin-sensitive adenylate cyclase ((EC ATP pyrophosphate-lyase (cyclizing)) in purified rat ovarian plasma membranes is stimulated by lutropin 2- to 3-fold in the absence, but 15- to 20-fold in the presence of GTP or p(NH)ppG. Following 10 to 15 min of incubation at 30 degrees C in the presence of lutropin, enzyme activity declined (50%) in the(More)
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