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Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to yeast Rad1 and found that it corrects the repair defects of XP group F as well as rodent groups 4 and 11. Causative mutations and strongly reduced levels of encoded protein were(More)
Male spermatogenesis is a complex biological process that is regulated by hormonal signals from the hypothalamus (GnRH), the pituitary gonadotropins (LH and FSH) and the testis (androgens, inhibin). The two key somatic cell types of the testis, Leydig and Sertoli cells, respond to gonadotropins and androgens and regulate the development and maturation of(More)
This longitudinal study examined links between disorganization and atypical maternal behavior at 12 and 24 months in 71 adolescent mother-child dyads. Organized attachment and maternal not disrupted behavior were more stable than disorganization and disrupted behavior, respectively. At both ages, disorganization and maternal disrupted behavior were(More)
CASE A 56-year-old female presented to the emergency department (ED) with a chief complaint of urinary retention and overflow incontinence for 24 hours, preceded by progressive difficulty with voiding, worsening lower abdominal discomfort and bloating. Her past medical history was significant for small bowel obstruction and neurofibromatosis with an(More)
This paper examines and contrasts two approaches to collecting behavioural data within the home. The first of these involves filming from static video cameras combined with network logging to capture media consumption activities across multiple screens. The second utilises wearable cameras that passively collect still images to provide insights into food(More)
The purpose was to examine the differences in kinesthetic ability, at the elbow joint, between children with (n = 15) and without (n= 15) spastic hemiplegia. The Kin Com 125 AP isokinetic dynamometer Configuration Chattanooga was used. Results revealed significant (p < .05) interaction between participant groups and side which was a repeated measures factor(More)
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