Elizabeth Edkins

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Phenylalanine hydroxylase (PAH) is first detected in the liver of 21-day-gestation rats. Activity increases after birth, and in 10-day-postnatal rats it is about equal to that observed in the adult. The developmental pattern for the enzyme is reflected in the level of its mRNA determined by hybridization to 32P-cDNA, which is specific for PAH. Studies with(More)
Hepatocytes derived from foetal rat liver synthesize and secrete albumin and transferrin when maintained in primary culture. These proteins are produced for at least seven days under the conditions of culture. Studies on hepatocyte cultures derived from 12, 13, 14, 15 and 19-day foetal rats show that the maximal cellular rate of secretion of both proteins(More)
Thermal-IR imaging from space-borne and ground-based observatories was used to investigate the temperature, composition and aerosol structure of Jupiter’s Great Red Spot (GRS) and its temporal variability between 1995-2008. An elliptical warm core, extending over 8◦ of longitude and 3◦ of latitude, was observed within the cold anticyclonic vortex at 21◦S.(More)
In fetal rat liver explants maintained in organ culture, the addition of dexamethasone (4.6 X 10(-6)M) produced a 2- to 3-fold increase in the activity of argininosuccinate synthetase and in argininosuccinate lyase after 24 and 48 h of incubation. Insulin (1.8 X 10(-6)M) alone had no effect on the enzyme activities, but when incubated together with(More)
INTRODUCTION Eccrine sweat glands are present across almost the entire body surface. The distinction between glabrous (hairless) and non-glabrous skin has frequently been used to describe differences in human sudomotor function, and, in particular, to help differentiate between the thermal and nonthermal mechanisms that modulate sweat secretion. Indeed, the(More)
Liver explants from 19-day foetal rats were maintained in organ culture, in a defined medium, for up to 48h. Both 6-N,2'-O-dibutyryl cyclic AMP, in the presence of theophylline, and dexamethasone caused an increase in the activities of carbamoyl phosphate synthase, argininosuccinate synthetase, argininosuccinate lyase and arginase. These increases could be(More)
Hormonal agents are used clinically to accelerate biochemical development and enhance functional maturation of small pre-term newborn infants. Present knowledge in the area of hormonal regulation of enzyme maturation in fetal tissues is still rudimentary and needs much further exploration.We have studied the effects of dexamethasone and cyclic AMP on the(More)
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