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Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping
Dopamine (DA) neurons in the midbrain ventral tegmental area (VTA) integrate complex inputs to encode multiple signals that influence motivated behaviors via diverse projections. Here, we combineExpand
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Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement
Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous establishedExpand
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Perceptual Learning Directs Auditory Cortical Map Reorganization through Top-Down Influences
The primary sensory cortex is positioned at a confluence of bottom-up dedicated sensory inputs and top-down inputs related to higher-order sensory features, attentional state, and behavioralExpand
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A Causal Link Between Prediction Errors, Dopamine Neurons and Learning
Situations in which rewards are unexpectedly obtained or withheld represent opportunities for new learning. Often, this learning includes identifying cues that predict reward availability. UnexpectedExpand
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Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons
Ventral tegmental area (VTA) dopamine (DA) neurons have been implicated in reward, aversion, salience, cognition, and several neuropsychiatric disorders. Optogenetic approaches involving transgenicExpand
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Positive Reinforcement Mediated by Midbrain Dopamine Neurons Requires D1 and D2 Receptor Activation in the Nucleus Accumbens
The neural basis of positive reinforcement is often studied in the laboratory using intracranial self-stimulation (ICSS), a simple behavioral model in which subjects perform an action in order toExpand
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Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
The extensively abused recreational drug MDMA has shown promise as an adjunct to psychotherapy for treatment-resistant psychiatric disease. It is unknown, however, whether the mechanisms underlyingExpand
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Causal roles for dopamine neurons in learned appetitive behaviors
Author(s): Steinberg, Elizabeth Eugenia | Advisor(s): Janak, Patricia H | Abstract: Much of the behavior of humans and other animals is directed towards seeking out edible, social, cognitive or drugExpand