Elizabeth E Baumann

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CONTEXT We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS). OBJECTIVE We tested the hypothesis that parental MBS is related to the PCOS phenotype in their offspring. DESIGN/SETTING We phenotyped for MBS and PCOS in our General Clinical Research Center. PATIENTS Girls with PCOS, 12-19 yr old (n = 36,(More)
OBJECTIVE It is often difficult to determine the pathophysiology of childhood diabetes at onset, particularly in overweight children, because obesity has been associated with both type 1 and type 2 diabetes. We compared children at the diagnosis of diabetes in a multiethnic population-based registry to understand the epidemiology of the disease during a(More)
Insulin dependent diabetes mellitus (IDDM) is likely to be due to the immunologic destruction of the islets of Langerhans. However, the relative importance of expression of a unique set of islet antigens or of differences in immune responses to those antigens in determining susceptibility to auto-immune diabetes is unknown. To a large extent, the reason for(More)
The acquisition of T-cell tolerance in the thymus is limited to those antigens expressed in the thymus at the time of T-cell development. Normally, islet antigens that are involved in insulin-dependent diabetes mellitus (IDDM) are not present in the thymus, but we have previously shown that transplantation of islets expressing relevant antigens into the(More)
This paper describes technical progress made in maturing ISHM technologies for hybrid diagnostic reasoners under NASA's Exploration Systems Research & Technology (ESR&T) program by Northrop Grumman Corporation and its NASA partners at ARC, GRC, JPL, and JSC A layered architecture was developed that supports both distributed and hierarchical(More)