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The glutamate receptor (GluR) agonist-binding site consists of amino acid residues in the extracellular S1 and S2 domains in the N-terminal and M3-M4 loop regions, respectively. In the present study, we sought to confirm that the conserved ligand-binding residues identified in the AMPA receptor S1S2 domains also participate in ligand binding of GluR6(More)
The glutamate receptor (GluR) agonist-binding site consists of amino acid residues in the extracellular S1 and S2 segments in the N-terminal and M3-M4 loop regions, respectively. Molecular and atomic level structural analyses have identified specific S1 and S2 residues that interact directly with ligands, interact with one another in a dimeric(More)
The absolute proton affinities of the nonprotein amino acids canavanine and canaline have been determined using the extended kinetic method in an electrospray ionization quadrupole ion trap instrument. Canavanine results from the substitution of an oxygen atom for the delta-CH2 group in the side chain of the protein amino acid arginine, whereas canaline(More)
Measurement of duration of fixation was used to assess the ability of 6-, 12-, 24-, and 36-week-old infants to discriminate black-and-white square-wave gratings from a homogeneous gray field at a distance of 20 ft (6.1 m). Acuity was estimated as the smallest stripe width detectable by at least 18 of the 24 infants in a given age group. The strip width was(More)
In two experiments preschool children chose one of two test forms that looked like previously exposed distortions of a letterlike-form. In Exp. I a distance metric was defined to measure the physical discrepancy between forms. It was found that the distance relationship between distortions and particular test forms did not designate the children's choice(More)
Whether it's an outage, scheduled maintenance or an announcement about a new technology resource, the pressure is on you to create effective and readable messages. Henry David Thoreau once said that he had received no more than one or two letters in his life that were worth the postage. To be sure, most of your communications don't require postage and won't(More)
Atomic clocks based on laser-cooled atoms have made tremendous advances in both accuracy and stability. However, advanced clocks have not found their way into widespread use because there has been little need for such high performance in real-world/commercial applications. The drive in the commercial world favours smaller, lower-power, more robust compact(More)
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