Elizabeth Carlsen

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THE UPTAKE OF GASES SUCH AS OXYGEN, CARBON MONOXIDE, OR NITRIC OXIDE BY THE ERYTHROCYTE INVOLVES: (a) diffusion across the cellular membrane, (b) intraerythrocytic diffusion, and (c) chemical combination with hemoglobin. The aim of this investigation was to obtain data which would permit an analysis of each of these factors in limiting the rate of gas(More)
When red blood cells from individuals with sickle cell anemia (S-S) undergo the characteristic shape transformation from biconcave disk to sickle, they lose potassium and gain sodium without appreciable change in total cation content or volume (1). Experiments using tracer K s indicate that sickling accelerates K influx as well as outflux (2). The present(More)
The conversion of red cells of patients with sickle cell anemia (S-S) from biconcave disk to sickle shape by removal of oxygen was found to increase the fraction of medium trapped in cells packed by centrifugation from 0.036 (S.E. 0.003) to 0.106 (S.E. 0.004). The fraction of water in the cells (corrected for trapped medium) was not affected by this shape(More)
At least two properties of red blood cells from patients with sickle cell anemia (S-S) are known to depend on the oxygen tension in the cell suspension. These are the shape (1), and the sodium and potassium content (2) of the cells. Evidence from several sources, recently reviewed by Itano (3), indicates that the characteristic metamorphosis from biconcave(More)
The uptake of gases such as oxygen, carbon monoxide, or nitric oxide by the erythrocyte involves: (a) diffusion across the cellular membrane, (b) intraerythrocytic diffusion, and (c) chemical combination with hemoglobin. The aim of this investigation was to obtain data which would permit an analysis of each of these factors in limiting the rate of gas(More)
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