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Greater physical activity and cardiorespiratory fitness are associated with reduced age-related cognitive decline and lower risk for dementia. However, significant gaps remain in the understanding of how physical activity and fitness protect the brain from adverse effects of brain aging. The primary goal of the current study was to empirically evaluate the(More)
BACKGROUND The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of breast cancer. METHODS A total of 358 survivors of breast cancer wore an accelerometer for 7 days at baseline to(More)
OBJECTIVES To examine the relationship between performance on executive function measures and subsequent mobility outcomes in community-dwelling older adults. DESIGN Randomized controlled clinical trial. SETTING Champaign-Urbana, Illinois. PARTICIPANTS Community-dwelling older adults (N = 179; mean age 66.4). INTERVENTION A 12-month exercise trial(More)
White matter structure declines with advancing age and has been associated with a decline in memory and executive processes in older adulthood. Yet, recent research suggests that higher physical activity and fitness levels may be associated with less white matter degeneration in late life, although the tract-specificity of this relationship is not well(More)
As breast cancer treatment is associated with declines in brain and cognitive health, it is important to identify strategies to enhance the cognitive vitality of cancer survivors. In particular, the hippocampus is known to play an important role in brain and memory declines following cancer treatment. The hippocampus is also known for its plasticity and(More)
BACKGROUND This study examined the effects of cardiorespiratory fitness, heart rate recovery, and physical activity on working memory in breast cancer survivors and age-matched controls. METHOD Using a case-control design, 32 women who had received a breast cancer diagnosis and completed primary treatment within the past 36-months (11 radiation only; 21(More)
Increased survival rates among breast cancer patients have drawn significant attention to consequences of both the presence of cancer, and the subsequent treatment-related impact on the brain. The incidence of breast cancer and the effects of treatment often result in alterations in the microstructure of white matter and impaired cognitive functioning.(More)
The use of multimedia to influence health behaviors offers unique advantages over more traditional center-based programs, however, little is known about the effectiveness of such approaches in improving physical activity levels over time. The purpose of this study was to examine the efficacy of a progressive and age-appropriate, DVD-delivered exercise(More)
BACKGROUND Previous research supports the efficacy of a 6-month DVD-delivered program for enhancing physical activity (PA) in older adults. In the current study, we examined the degree to which intervention-related increases in PA were maintained after a 6-month, no-contact follow-up. METHODS Follow-up assessments of PA via accelerometry and the Godin(More)