Elizabeth Allen

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BACKGROUND Severe acute respiratory failure in adults causes high mortality despite improvements in ventilation techniques and other treatments (eg, steroids, prone positioning, bronchoscopy, and inhaled nitric oxide). We aimed to delineate the safety, clinical efficacy, and cost-effectiveness of extracorporeal membrane oxygenation (ECMO) compared with(More)
BACKGROUND Increased consumption of n-3 (omega-3) long-chain polyunsaturated fatty acids (LC PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may maintain cognitive function in later life. OBJECTIVE We tested the hypothesis that n-3 LC PUFA supplementation would benefit cognitive function in cognitively healthy older people.(More)
CONTEXT Research on young people's sexual relationships often overlooks subjective experiences and enjoyment. Perceived quality of sexual relationships may be related to gender, background characteristics, circumstances of first intercourse and subsequent sexual history. METHODS Longitudinal data from 13-16-year-olds who participated in randomized trials(More)
OBJECTIVE To investigate the effect of highly active antiretroviral therapy (HAART) on Kaposi sarcoma-associated herpesvirus (KSHV) DNA load, anti-KSHV antibody responses and KSHV-specific CD8 T cell responses in HIV-infected individuals over a 2 year period. DESIGN Prospective study of 27 HIV-infected antiretroviral therapy-naive individuals, with (n =(More)
BACKGROUND Despite a decline in incidence of Pneumocystis jirovecii pneumonia (PCP), severe PCP continues to be a common cause of admission to the intensive care unit (ICU) where mortality remains high. A study was undertaken to examine the outcome from intensive care for patients with PCP and to identify prognostic factors. METHODS A retrospective cohort(More)
OBJECTIVE To ascertain mortality from 1 to 18 years, and predictors of mortality. DESIGN Long-term follow-up of population cohort born 1989-1992. SETTING Births in South East Thames Region. PATIENTS 346 children with bilateral cerebral palsy (CP). INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Mortality; predictors of mortality. RESULTS 98%(More)
BACKGROUND Improving the health of school-aged children can yield substantial benefits for cognitive development and educational achievement. However, there is limited experimental evidence of the benefits of alternative school-based malaria interventions or how the impacts of interventions vary according to intensity of malaria transmission. We(More)
BACKGROUND Improvement of sex education in schools is a key part of the UK government's strategy to reduce teenage pregnancy in England. We examined the effectiveness of one form of peer-led sex education in a school-based randomised trial of over 8000 pupils. METHODS 29 schools were randomised to either peer-led sex education (intervention) or to(More)
In 2005, the Lancet Neonatal Survival Series highlighted the fact that 4 million babies die in the neonatal period; 99% of these deaths arise in low-income and middle-income countries. Globally, 23% of neonatal deaths are directly related to birth asphyxia; additionally, birth asphyxia leads to a substantial burden of longterm neurological disability and(More)