Elizabeth A. Martin

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Drug-Induced Oxidative Stress and Toxicity

Damian G. Deavall, Elizabeth A. Martin, Judith M. Horner, Ruth A Roberts
Journal of toxicology
2012

Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that… (More)

hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.

Catherine C Smith, Michael Richard O'Donovan, Elizabeth A. Martin
Mutagenesis
2006

The European Standards Committee on Oxidative DNA Damage (ESCODD) recommended the use of the lesion-specific repair enzyme, formamidopyrimidine DNA-glycosylase (FPG) in the comet assay to detect… (More)

Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia.

Philip Carthew, Richard E. Edwards, +4 authors Michael J. Tucker
Carcinogenesis
2000

Tamoxifen was administered orally to neonatal rats on days 2-5 after birth and the subsequent effects on the uterus were characterized, morphometrically, over the following 12 months. Tamoxifen… (More)

BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining.

Paul T J Scheepers, David Coggon, +15 authors Iris Zwirner-Baier
Toxicology letters
2002

Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of… (More)

Tamoxifen associated uterine pathology in rodents: relevance to women.

Philip Carthew, Richard E. Edwards, Barbara M. Nolan, Elizabeth A. Martin, Lewis L. Smith
Carcinogenesis
1996

Rats administered tamoxifen for 3 months and then returned to a basal diet developed an increase in uterine weight for up to 9 months after tamoxifen exposure. Stereological analysis of the tamoxifen… (More)

Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage.

Matthew W Himmelstein, Peter J Boogaard, +5 authors David E. G. Shuker
Critical reviews in toxicology
2009

The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse consequences for cellular and whole organism function. Available methods for identification of DNA damage and… (More)

Presence of benzo[a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations.

Michael N. Routledge, Keith I. E. McLuckie, George D. D. Jones, Peter B. Farmer, Elizabeth A. Martin
Carcinogenesis
2001

Exposure to DNA damaging agents and mutagens often occurs as combinations of agents, or as complex mixtures of chemicals. We found that plasmid DNA adducted with benzo[a]pyrene diol epoxide (BPDE)… (More)

Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry.

Elizabeth A. Martin, Karen R. Brown, +9 authors Ian H. White
Cancer research
2003

This study was aimed to establish whether tamoxifen binds irreversibly to uterine DNA when given to women. Patients were given a single therapeutic dose of [(14)C]tamoxifen citrate orally (20 mg,… (More)

Mutation spectra induced by alpha-acetoxytamoxifen-DNA adducts in human DNA repair proficient and deficient (xeroderma pigmentosum complementation group A) cells.

Keith I. E. McLuckie, Robert J R Crookston, +4 authors Karen Brown
Biochemistry
2005

Tamoxifen, a breast cancer drug, has recently been approved for the chemoprevention of this disease. However, tamoxifen causes hepatic carcinomas in rats through a genotoxic mechanism and increases… (More)

Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy.

Dianne Khurana, Elizabeth A. Martin, +4 authors Scott E. Strome
Head & neck
2001

BACKGROUND To develop novel therapeutic approaches for patients with head and neck malignancies, poorly immunogenic murine models of squamous cell carcinoma (SCC) need to be defined. METHODS The… (More)

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