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- Damian G. Deavall, Elizabeth A. Martin, Judith M. Horner, Ruth A Roberts
- Journal of toxicology
- 2012
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that… (More)
- Catherine C Smith, Michael Richard O'Donovan, Elizabeth A. Martin
- Mutagenesis
- 2006
The European Standards Committee on Oxidative DNA Damage (ESCODD) recommended the use of the lesion-specific repair enzyme, formamidopyrimidine DNA-glycosylase (FPG) in the comet assay to detect… (More)
- Elizabeth A. Martin, Karen T. Brown, +9 authors Ian H. White
- Cancer research
- 2003
This study was aimed to establish whether tamoxifen binds irreversibly to uterine DNA when given to women. Patients were given a single therapeutic dose of [(14)C]tamoxifen citrate orally (20 mg,… (More)
- Matthew W Himmelstein, Peter J Boogaard, +5 authors David E. G. Shuker
- Critical reviews in toxicology
- 2009
The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse consequences for cellular and whole organism function. Available methods for identification of DNA damage and… (More)
- Paul T J Scheepers, David Coggon, +15 authors Iris Zwirner-Baier
- Toxicology letters
- 2002
Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of… (More)
- Philip Carthew, Richard E. Edwards, +4 authors Michael J. Tucker
- Carcinogenesis
- 2000
Tamoxifen was administered orally to neonatal rats on days 2-5 after birth and the subsequent effects on the uterus were characterized, morphometrically, over the following 12 months. Tamoxifen… (More)
- Dianne Khurana, Elizabeth A. Martin, +4 authors Scott E. Strome
- Head & neck
- 2001
BACKGROUND
To develop novel therapeutic approaches for patients with head and neck malignancies, poorly immunogenic murine models of squamous cell carcinoma (SCC) need to be defined.
METHODS
The… (More)
- Philip Carthew, Richard E. Edwards, Barbara M. Nolan, Elizabeth A. Martin, Lewis L. Smith
- Carcinogenesis
- 1996
Rats administered tamoxifen for 3 months and then returned to a basal diet developed an increase in uterine weight for up to 9 months after tamoxifen exposure. Stereological analysis of the tamoxifen… (More)
- Lisbeth Ehlert Knudsen, Margaret Gaskell, +5 authors Peter B. Farmer
- Mutation research
- 2005
This study was performed in an Estonian shale-oil mine with the purpose to develop and apply a number of biomarkers for occupational diesel-exhaust exposure monitoring. Increased breathing-zone… (More)
- Keith I. E. McLuckie, Robert J R Crookston, +4 authors Karen Brown
- Biochemistry
- 2005
Tamoxifen, a breast cancer drug, has recently been approved for the chemoprevention of this disease. However, tamoxifen causes hepatic carcinomas in rats through a genotoxic mechanism and increases… (More)