Elizabeth A. McQuigan

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To determine the toxicities and pharmacokinetic effects of eniluracil (EU) given on two weekly dosing schedules with 5-fluorouracil (5-FU) and leucovorin (LV). A group of 26 patients received a single 24-h i.v. infusion of 5-FU 2300 mg/m2 to provide a pharmacokinetic reference. After 2 weeks, patients received oral EU 20 mg plus LV 30 mg on days 1–3 with a(More)
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