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Small animals such as nematodes and insects analyze airborne chemical cues to infer the direction of favorable and noxious locations. In these animals, the study of navigational behavior evoked by airborne cues has been limited by the difficulty of precisely controlling stimuli. We present a system that can be used to deliver gaseous stimuli in defined(More)
When placed on a temperature gradient, a Drosophila larva navigates away from excessive cold or heat by regulating the size, frequency, and direction of reorientation maneuvers between successive periods of forward movement. Forward movement is driven by peristalsis waves that travel from tail to head. During each reorientation maneuver, the larva pauses(More)
The avoidance of light by fly larvae is a classic paradigm for sensorimotor behavior. Here, we use behavioral assays and video microscopy to quantify the sensorimotor structure of phototaxis using the Drosophila larva. Larval locomotion is composed of sequences of runs (periods of forward movement) that are interrupted by abrupt turns, during which the(More)
Complex animal behaviors are built from dynamical relationships between sensory inputs, neuronal activity, and motor outputs in patterns with strategic value. Connecting these patterns illuminates how nervous systems compute behavior. Here, we study Drosophila larva navigation up temperature gradients toward preferred temperatures (positive thermotaxis). By(More)
Circadian rhythms offer an excellent opportunity to dissect the neural circuits underlying innate behavior because the genes and neurons involved are relatively well understood. We first sought to understand how Drosophila clock neurons interact in the simple circuit that generates circadian rhythms in larval light avoidance. We used genetics to manipulate(More)
1579 PeRsPeCtiVes findings do not rule out a role for mTORC2 in aging. What Lamming et al. do achieve is a clear dissociation of impaired glucose homeostasis and enhanced longevity. Indeed, mtor +/− mlst8 +/− mice have normal glucose homeostasis, indicating that delayed aging derives from some other consequence(s) of mTORC1 inhibition. Considerable effort(More)
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT Small animals like nematodes and insects are highly olfactory, capable of analyzing airborne chemical cues to infer the direction of favorable and noxious locations. In these animals, the study of navigational behavior evoked(More)
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