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OBJECTIVE To examine the effect of an exercise and dietary intervention during pregnancy on excessive gestational weight gain (EGWG), dietary habit and physical activity in pregnant women. DESIGN Randomised controlled trial. SETTING Community-based study. POPULATION Nondiabetic urban-living pregnant women (<26 weeks of gestation). METHODS(More)
OBJECTIVE To evaluate the risk of complications in youth with type 2 diabetes. RESEARCH DESIGN AND METHODS Population-based cohorts of 342 youth (1-18 years of age) with prevalent type 2 diabetes, 1,011 youth with type 1 diabetes, and 1,710 nondiabetic control youth were identified between 1986 and 2007 from a clinical registry and linked to health care(More)
T HE PRINCIPAL ALTERATION in heat balance which occurs in rats exposed to a moderately cold environment is characterized bY an increased produ ction of heat, rather than by a decrease in its loss. This has been demonstrated by the measurement of oxygen consumption, and by direct calorimetry (1-3). Increased oxygen consumption in the cold can be attributed(More)
BACKGROUND Type 2 diabetes mellitus is increasingly being observed among children and youth, including the Native population of Canada. Only one study has investigated prenatal and early infancy risk factors for the disease. METHODS A case-control study was conducted; 46 patients younger than 18 years were recruited from the only clinical center for the(More)
OBJECTIVE To investigate the prevalence of the unique HNF-1alpha G319S mutation in a population of aboriginal youth with type 2 diabetes and to describe the relationship between clinical and historical characteristics and the presence or absence of the HNF-1alpha G319S mutation. RESEARCH DESIGN AND METHODS Participating youth were genotyped for the G319S(More)
OBJECTIVE To compare the prevalence of risk factors in children aged <18 years diagnosed with medication-induced diabetes mellitus versus those diagnosed with type 2 diabetes. STUDY DESIGN This retrospective observational study used data from a Canadian prospective surveillance study in which clinical features of new cases of type 2 diabetes (n = 225) and(More)