Eliza Glodkowska-Mrowka

Learn More
OBJECTIVE Considering the increasing number of clinical observations indicating hyperglycemic effects of statins, this study was designed to measure the influence of statins on the uptake of glucose analogs by human cells derived from liver, adipose tissue, and skeletal muscle. DESIGN Flow cytometry and scintillation counting were used to measure the(More)
Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum (ER)-resident chaperone and a major regulator of the unfolded protein response (UPR). Accumulating evidence indicate that GRP78 is overexpressed in many cancer cell lines, and contributes to the invasion and metastasis in many human tumors. Besides, GRP78 upregulation is detected in response(More)
Activation of adaptive mechanisms plays a crucial role in cancer progression and drug resistance by allowing cell survival under stressful conditions. Therefore, inhibition of the adaptive response is considered as a prospective therapeutic strategy. The PERK-eIF2α phosphorylation pathway is an important arm of the unfolded protein response (UPR), which is(More)
BRAF mutation testing is one of the best examples how modern genetic testing may help to effectively use targeted therapies in cancer patients. Since many different genetic techniques are employed to assess BRAF mutation status with no available comparison of their sensitivity and usefulness for different types of samples, we decided to evaluate our own(More)
Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks (DSBs) to stimulate repair of these potentially lethal DNA lesions. FANCD2-Ub was upregulated in CD34+ chronic myeloid leukemia (CML) cells and in BCR-ABL1 kinase-positive cell lines in response to elevated levels of reactive oxygen species (ROS) and DNA(More)
PPARγ ligands increase antileukemic activity of second-and third-generation tyrosine kinase inhibitors in chronic myeloid leukemia cells BCR-ABL1 tyrosine kinase inhibitors (TKIs) have revolutionized the therapy of chronic myeloid leukemia (CML) and converted it into a truly chronic disease. However, there is still a significant group of patients who do not(More)
Pr ecis: Preclinical studies validate a novel class of small molecule inhibitors of the enzyme GSK-3, which exert potent antitumor properties by blocking both tumor invasion and angiogenesis. Pr ecis: The lack of a complete cytogenetic response in chronic phase CML patients treated with the ABL kinase inhibitor imatinib can be explained by loss of the(More)
  • 1