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A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity.

• Andréi Maksimenko, Franco Dosio, +9 authors Patrick Couvreur
• Proceedings of the National Academy of Sciences…
• 2014

We identified that the chemical linkage of the anticancer drug doxorubicin onto squalene, a natural lipid precursor of the cholesterol's biosynthesis, led to the formation of squalenoyl doxorubicin… (More)

Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma.

• Mouna Raouane, Didier Desmaele, +9 authors Patrick Couvreur
• Journal of medicinal chemistry
• 2011

We report the conjugation of the natural lipid squalene (SQ) with a small interfering RNA (siRNA), against the junction oncogene RET/PTC1, usually found in papillary thyroid carcinoma (PTC). The… (More)

Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy.

• Andréi Maksimenko, Julie Mougin, +7 authors Patrick Couvreur
• Cancer letters
• 2013

A series of new polyisoprenoyl prodrugs of gemcitabine, which can be formulated as nanoassemblies are described. These prodrugs were designed to improve gemcitabine efficacy and to overcome the… (More)

Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene.

• Joachim Caron, Andréi Maksimenko, +6 authors Didier Desmaële
• Advanced healthcare materials
• 2013

A series of new lipid prodrugs of paclitaxel, which can be formulated as nanoassemblies, are described. These prodrugs which are designed to overcome the limitations due to the systemic toxicity and… (More)

Nanomedicine as a potent strategy in melanoma tumor microenvironment.

• Vincent Pautu, Daniela Leonetti, Elise Lepeltier, Nicolas Clere, Catherine Passirani
• Pharmacological research
• 2017

Melanoma originated from melanocytes is the most aggressive type of skin cancer. Despite considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors and monoclonal… (More)

Development and evaluation of injectable nanosized drug delivery systems for apigenin.

• Reatul Karim, Claudio Palazzo, +9 authors Géraldine Piel
• International journal of pharmaceutics
• 2017

The purpose of this study was to develop different injectable nanosized drug delivery systems (NDDSs) i.e. liposome, lipid nanocapsule (LNC) and polymeric nanocapsule (PNC) encapsulating apigenin… (More)

Melanoma tumour vasculature heterogeneity: from mice models to human

• Vincent Pautu, Adélie Mellinger, +6 authors Nicolas Clere
• Journal of Cancer Research and Clinical Oncology
• 2018

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of… (More)

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity.

• Erdem Kanber, Hiroe Yamada, Brigitta Loretz, Elise Lepeltier, Claus-Michael Lehr
• Bioconjugate chemistry
• 2016

Nucleotide analogues are a therapeutic class that is very promising and currently used in clinics, notably against viral infectious diseases and cancer. However, their therapeutic potential is often… (More)

Enhanced and preferential internalization of lipid nanocapsules into human glioblastoma cells: effect of a surface-functionalizing NFL peptide.

• Reatul Karim, Elise Lepeltier, +8 authors Catherine Passirani
• Nanoscale
• 2018

Increasing intracellular drug concentration using nanocarriers can be a potential strategy to improve efficacy against glioblastoma (GBM). Here, the fluorescent-labelled NFL-TBS·40-63 peptide… (More)

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