Elisabetta Bignamini

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BACKGROUND To date, few studies have been published regarding the number of children in Italy who require long-term mechanical ventilation (LTV) and their underlying diagnoses, ventilatory needs and hospital discharge rate. METHODS A preliminary national postal survey was conducted and identified 535 children from 57 centers. Detailed data were then(More)
Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and reviewed in order to identify the factors that lead to more favourable outcomes. Large data repositories, such as the US Cystic Fibrosis Registry, which was established in the 1960s, enabled successful treatments and patient outcomes to be recognized and(More)
BACKGROUND Improved technology, as well as professional and parental awareness, enable many ventilator-dependent children to live at home. However, the profile of this growing population, the quality and adequacy of home care, and patients' needs still require thorough assessment. OBJECTIVES To define the characteristics of Italian children receiving(More)
BACKGROUND Spinal muscular atrophy type 1 (SMA1) is a progressive disease and is usually fatal in the first year of life. METHODS A retrospective chart review was performed of SMA1 patients and their outcomes according to the following choices: letting nature take its course (NT); tracheostomy and invasive mechanical ventilation (TV); continuous(More)
Since the severity of pulmonary phenotype in cystic fibrosis (CF) is not definitely dependent on the CF transmembrane conductance regulator (CTFR) genotype, attention was recently focused on to the possible role of several modifier genes and related physiopathologic mechanisms [1]. In particular, reduced in vitro activity of the lysosomal enzyme(More)
We report here 2 pediatric cases of multidrug-resistant (MDR) tuberculosis (TB) that were observed in Italy. Both families came from an Eastern European country, which is notably an area with a high prevalence of MDR TB. An increase of new cases of MDR TB in developed countries is expected over the next years because of migratory flow, and specific measures(More)
The aims of this paper are: to examine the physiological rationale for noninvasive respiratory support (NRS) in children with acute respiratory failure (ARF); to review clinical available data and to give some practical recommendations to its safe application. NRS is the delivery of ventilatory support without the need of an invasive airway. Two types of(More)
BACKGROUND The aims of this study were to verify the feasibility of respiratory function tests and to assess their validity in the diagnosis of respiratory disorders in young children. METHODS We performed spirometry and collected information on health and parents' lifestyle on a sample of 960 children aged 3-6. RESULTS The cooperation rate was 95.3%.(More)
UNLABELLED Oxidative stress plays an important role in cystic fibrosis (CF). However, there is a lack of validated biomarkers of oxidative damage that correlate with the antioxidant needs of patients with CF. OBJECTIVE To investigate oxidative stress in stable pediatric CF patients and evaluate if vitamin supplementation may be tailored to individual(More)
AIM In recent years many consensus conferences of scientific societies have reaffirmed the advantages of metered dose inhalator (MDI) and spacer administration compared to classic aerosol in acute asthma and maintenance therapy. Faced with a more than convincing documentation, the practitioners have shown a controversial attitude concerning this type of(More)