Elisabeth Trouche

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In the primate striatum, the tonically discharging neurons respond to conditioned stimuli associated with reward. We investigated whether these neurons respond to the reward itself and how changes in the behavioral context in which the reward is delivered might influence their responsiveness. A total of 286 neurons in the caudate nucleus and putamen were(More)
To test whether the responsiveness of tonically discharging neurons from monkey striatum is dependent on the motor or rewarding features of the conditioned stimuli, we studied the responses of these neurons to visual stimuli presented under two behavioral conditions: during an operant task in which the stimulus triggered a movement to obtain a reward, and(More)
Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual stimulus in the initial position S1; P2,(More)
Unilateral electrolytic lesions of the substantia nigra (SN) were carried out stereotaxically on 4 baboons which had been previously trained to perform a visually guided pointing movement. For a few days after operation, all animals exhibited a behavioral impairment affecting the contralateral body half and consisting of dystonic flexed posture and(More)
Unilateral lesions of the nigrostriatal dopaminergic system were induced in five monkeys by intranigral injections of the neurotoxin 6-hydroxydopamine. Following the lesion, all monkeys showed a transient reluctance in using the contralateral forelimb, accompanied, in two monkeys by semi-flexed posture of the disabled forelimb. Three of the monkeys that had(More)
In monkeys performing a pointing movement, reaction times (RTs) had been studied after permanent exclusion or reversible cooling of the internal pallidal segment. The results show a significant diminution of RT in all treated animals. The role of the internal pallidal segment on the preparatory phase of the motor act is emphasized.
The ability of 13 Parkinsonian patients and 11 age-matched control subjects to process and use two components of the information given prior to a voluntary movement was studied using reaction time (RT) tasks. This advance information about the direction of a pointing movement was given using a double stimulation paradigm with an auditory warning signal (WS)(More)
The effects of globus pallidus (GP) lesion were examined in two monkeys trained to perform a visually guided pointing movement in simple and choice reaction time tasks involving small and large amplitude movements. The reaction time (RT) and the movement time (MT) were measured. The Y-axis error (EY) was also analyzed in order to assess the movement(More)
The functional role of the putamen, in both initiation and execution of a motor act, was investigated in 3 baboons performing a visuomotor pointing task. Reversible blockade of the putamen differentially affected the spatiotemporal components of the response. The results stress the importance of the putamen in the triggering of a goal-directed movement, but(More)
In studies on the motor impairments induced in monkeys by performing lesions of various kinds on the central nervous system, it is necessary to be able to exactly quantify the motor deficits. The battery of tests described in the present paper (simple and choice reaction-time procedures, goal-directed pointing movement, digital manipulation task) provide a(More)