Elisabeth Schick

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OBJECTIVE This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I. DESIGN The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group study in a clinical research unit in(More)
Zwei Patienten mit chronischer myeloischer Leukämie (CML) entwickelten während einer Hydroxyurea (Litalir ® )-Langzeittherapie dermatomyositisartige Veränderungen an den Händen. Beide Patienten zeigten neben unspezifischen Hautveränderungen, wie sie auch nach anderen Zytostatika vorkommen, so Hauttrockenheit, Pruritus, Hyperpigmentierungen etc., für(More)
Although coronary artery bypass grafting effectively reduces the symptoms of myocardial ischemia, its immediate effect on regional wall motion dysfunction is not well defined. This intraoperative study was undertaken to determine whether bypass grafting improves regional wall motion in areas of preoperative ischemic dysfunction. In 17 patients undergoing(More)
Despite its value in the diagnosis of pericardial disease, two-dimensional echocardiography also is known to produce confounding results. Ten patients had juxtacardiac masses simulating pericardial tumor implants on echocardiographic examination ("pericardial pseudotumor") caused by juxtacardiac pulmonary atelectasis or lobar collapse. The atelectatic(More)
Ten patients with advanced renal carcinoma were treated by ifosfamide (50–60 mg/kg/dayx5 days). The treatment was repeated every 4 weeks and continued until progression appeared. Two patients came into partial remission, two had subjective improvement, and six did not respond. Seven patients developed acute psychopathological symptoms during the first(More)
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