Elisabeth Lindner

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Forskolin is a positive inotropic-acting and blood pressure lowering agent which was isolated from the Indian plant Coleus forskohlii. In isolated heart tissue, forskolin activates a membrane bound adenylatecyclase and a cytoplasmic cAMP-dependent protein kinase to a much higher degree than does isoprenaline. This activation does not require the hormone(More)
Four heavy metal staining methods have been applied to frog lung surfactant. Among them, the iodoplatinate method is the only one that almost exclusively visualizes the phospholipid moiety being produced in the lamellated bodies of the pulmonary epithelial cells and forming the backbone of organized structures within the extracellular lining layer. The(More)
The contraction of the potassium depolarized pulmonary artery of the guinea pig was diminished by the calcium antagonists nifedipine, gallopamil, diltiazem, verapamil and prenylamine. The drugs are listed here in order of activity. The uptake of 45Ca of the depolarized pulmonary artery was reduced by nifedipine, verapamil and prenylamine in this order of(More)
Hyperoxaluria is a well-recognised risk factor for urolithiasis and patients with primary hyperoxaluria (PH) gradually build up calcium oxalate deposits leading to chronic kidney disease. Efforts to improve treatment for PH have focused on reducing urine oxalate excretion and thus decreasing lithogenesis. To determine the efficacy of treatments designed to(More)
Optimization of microcarrier processes is dependent upon efficient, serial subcultivation routines. Established methods have been modified for a high degree of cell detachment from microcarriers, and transfer of a maximum number of viable cells from one culture to the next during the scale up process. Cultures of MRC-5 and Vero cells were studied, and cell(More)
Primary hyperoxaluria (PH) is a rare, genetic disorder which involves the overproduction of endogenous oxalate, leading to hyperoxaluria, recurrent urolithiasis and/or progressive nephrocalcinosis and eventually resulting in kidney failure and systemic oxalosis. The aim of this trial was to investigate whether treatment involving an oxalate-metabolising(More)