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Salicylic acid (SA) is an important mediator of plant defense response. In Arabidopsis (Arabidopsis thaliana), this compound was proposed to derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1). Null ics1 mutants still accumulate some SA, suggesting the existence of an enzymatic activity… (More)
Microglia are the intrinsic immune cells of the brain. As such, they are crucially involved in neuro-protection as well as neuro-degeneration. Their activation leads to the induction of cytokine and chemokine release, the production of reactive oxygen species and nitric oxide and an increased outward potassium conductance. In this study, we focus our… (More)
1 Introduction: plant phenolics – secondary metabolites with diverse functions.
N No ou uv ve ea au ux x c co on nc ce ep pt ts s d da an ns s l la a p ph ha ar rm ma ac co ol lo og gi ie e d de es s r ré éc ce ep pt te eu ur rs s a au ux x a ac ci id de es s g gr ra as s à à c ch ha aî în ne e c co ou ur rt te e F FF FA A2 2 e et t F FF FA A3 3 [New insights into the pharmacology of the short-chain free fatty acid receptors 2 and 3]… (More)