Elisabeth F. Heuston

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Hematopoietic stem and progenitor cells (HSPCs) reside in a specialized niche that regulates their proliferative capacity and their fate. There is increasing evidence for similar roles of marrow niches on controlling the behavior of leukemic cells; however, whether normal hematopoietic stem cell (HSC) and leukemic cells reside in or functionally compete for(More)
Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework(More)
CEBPA is a transcription factor that acts as a master differentiation regulator in many tissues including liver, lung, adipose, and blood. Between 10% and 15% of acute myeloid leukemia (AML) subtypes haveCEBPA mutations or changes in CEBPA regulation that lead to a block in myeloid differentiation. Enhancers are regulatory regions of DNA that physically(More)
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