Elisabeth Buschmans

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Comparison of the action potent ia ls of hypertrophied and control rat hearts reveals the fol lowing for a l l types of hypertrophy: depending on the degree of hypertrophy, there is a var iously pronounced prolongation of the action potent ial with nearly unchanged amplitude, resting potent ial and max. upstroke ve loc i ty . In pressure-hypertrophied(More)
Forskolin increases intracellular cyclic AMP content by direct stimulation of adenylate-cyclase independently of the beta receptor. Studies have been carried out in two different types of isolated rat heart preparation to compare the cardiovascular effects of forskolin and isoprenaline. The inotropic and chronotropic properties of these drugs, together with(More)
It has been proposed that increases in tissue cyclic adenosine monophosphate during ischemia may be responsible for the induction of arrhythmias that occur during the early minutes of ischemia. We have tested this hypothesis using the isolated perfused rat heart with coronary artery occlusion for 30 minutes. In control hearts, after a transient small rise,(More)
The new inotropic agent, forskolin, is thought to act by stimulation of adenyl cyclase at a site remote from the beta-receptor. In this study we have characterized the action of forskolin in isolated, perfused rat and guinea-pig hearts. In both species, forskolin increased heart rate, left ventricular pressure and tissue cyclic AMP in a(More)
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