Elisabeth B. Walsh

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In the extracellular matrix (ECM), chemical cues are present that control all aspects of cell biology. These surfacebound and soluble factors provide the necessary adhesion and signaling for normal cellular activity, and without such matrix support, the cells will quickly apoptose. Implanted device surfaces lack the molecular features that provide guidance(More)
Amphiphilic macromolecules containing a polystyrene-adherent peptide domain and a cell-repellent poly(ethylene glycol) domain were designed, synthesized, and evaluated as a cytophobic surface coating. Such cytophobic, or cell-repellent, coatings are of interest for varied medical and biotechnological applications. The composition of the polystyrene binding(More)
Biomaterials used in implants have traditionally been selected based on their mechanical properties, chemical stability, and biocompatibility. However, the durability and clinical efficacy of implantable biomedical devices remain limited in part due to the absence of appropriate biological interactions at the implant interface and the lack of integration(More)
Identification of Polystyrene (PS)-Binding Sequences Polymer-binding sequences were identified using a phage display library developed from phage type M13. The library displayed random peptide sequences on its pIII coat proteins of the format X6YX6 or X6PX6, where X represents one of the twenty naturally occurring amino acids. For the panning procedure,(More)
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