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To initiate phi29 DNA replication, the DNA polymerase has to form a complex with the homologous primer terminal protein (TP) that further recognizes the replication origins of the homologous TP-DNAContinue Reading
  • Elisa Longás, Laurentino Villar, J. M. Lazaro, Miguel de Vega, Margarita Salas
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 November 2008
  • Bacteriophages phi29 and Nf from Bacillus subtilis start replication of their linear genome at both DNA ends by a protein-primed mechanism, by which the DNA polymerase, in a template-instructedContinue Reading
  • Alicia del Prado, José M. Lázaro, Elisa Longás, Laurentino Villar, Miguel de Vega, Margarita Salas
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 23 September 2015
  • Background: The initiation of replication in φ29 mainly occurs opposite the 3′ penultimate nucleotide of the template. Results: Mutations in the TP residue Phe-230 changed the specificity for theContinue Reading
  • Elisa Longás, Miguel de Vega, José María Lázaro, Margarita Salas
  • Biology, Medicine
  • Nucleic acids research
  • 1 November 2006
  • This paper shows that the protein-primed DNA polymerases encoded by bacteriophages Nf and GA-1, unlike other DNA polymerases, do not require unwinding or processivity factors for efficient synthesisContinue Reading