Elinore F. McCance

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The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly developed single photon emission computerized tomography method to measure amphetamine-induced dopamine release(More)
AIMS To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence and concurrent alcohol abuse or dependence. DESIGN Randomized controlled trial. SETTING Urban substance abuse treatment center. PARTICIPANTS One hundred and twenty-two cocaine/alcohol abusers (27% female; 61% African-American or(More)
OBJECTIVE The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies. METHOD [123I] beta-CIT and single photon emission computed tomography were used to assess striatal dopamine transporter levels in 28 cocaine-abusing subjects and 24(More)
The in vivo potency of euphorigenic doses of intravenous cocaine for displacing [123I]β-CIT ([123I]2β-carbomethoxy-3β-(4-iodophenyl)tropane) binding to striatal dopamine transporters (DAT) was assessed in human cocaine addicts using single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n=6) were injected with [123I]β-CIT and imaged(More)
Comorbid abuse of cocaine and alcohol is a common occurrence. Cocaethylene, the ethyl ester of benzoylecgonine, is an active metabolite formed as a result of simultaneous use of these substances. In humans, the concurrent ingestion of cocaine and alcohol, with resulting cocaethylene formation, has been associated with enhanced subjective euphoria, increased(More)
AIM To evaluate outcomes 1 year after cessation of treatment for cocaine- and alcohol-dependent individuals. DESIGN Randomized controlled trial. SETTING Urban substance abuse treatment center. PARTICIPANTS Ninety-six of 122 subjects randomized to treatment. INTERVENTIONS One of five treatments delivered over 12 weeks. Cognitive-behavioral treatment(More)
The search for a pharmacotherapeutic agent for the treatment of cocaine dependence began in the early 1980s as clinicians and researchers realized that the cocaine epidemic was growing rapidly and that standard drug counseling and self-help groups made little impact on the addiction for many cocaine abusers. Cocaine was initially viewed as a recreational(More)
Cocaethylene, an active metabolite that arises through hepatic transesterification of cocaine when cocaine and ethanol are used together, shares many neurochemical and pharmacological properties with cocaine. Cocaethylene is similar to cocaine in its properties as an indirect dopamine agonist, and human subjects cannot distinguish its effects from those of(More)